Design of experiments (DOE) is a part of statistics that provides tools for efficient experimentation. Although the subject started in an agricultural context, it is nowadays being applied in many areas, both in science and in industry. A model-oriented view, where some knowledge about the form of the data-generating process is assumed, naturally leads to the so-called optimum experimental design (OED).
Due to increasing competition, DOE has become crucial for modern industry, especially for product development. Since different industrial applications of DOE (especially those in pharmaceutical industries) may exhibit very special and varying characteristics, this model oriented approach with its tailor-made solutions is of advantage.
Just few scientists in Spain are focusing on the optimum experimental design. It could be fairly stated that the research groups in the University of Almería, University of Salamanca, University of Castilla-La Mancha, University of La Laguna, Public University of Navarra and University of Zaragoza are almost the only ones doing research in optimum designs theory applied to regression models. The “Optimum Designs Model Oriented Design and Analysis Conference”, mODa 8, took place in June 2007, 4th-8th, Almagro (Ciudad Real, Spain); the Local Organising Committee was composed by the members of the Optimum Experimental Design group.
The association of these groups has obtained some public funds from the Spanish Agency: Ministerio de Educación y Ciencia as well as from the corresponding Regional Administrations and Universities. The groups have also worked on several projects regarding different topics of Statistics, Probability and Operations Research. The group constitutes one of the eight nodes of the National Network of Biostatistics (BioStatNet), including some biomedical institutions:
- Wine cellar Salcedo Balmaseda
- Center for Cancer Systems Biology, Harvard University (Boston, U.S.A.)
- Research Center on Cancer, University of Salamanca (Salamanca, Spain)
- Department of Preventive Medicine and Public Health, University of Navarra (Pamplona, Spain)
- ENUSA Industrias Avanzadas S.A. (Madrid, Spain)
- Hospital Alto Deba, Mondragón – Arrasate (Guipuzcoa, Spain)
- European Bioinformatics Institute EBI (Cambridgeshire, United Kingdom)
- Research Group on Bioinformatic of CNB (Madrid, Spain)
- Research Group on Bioinformatic of CNIO (Madrid, Spain)
- Research Group on Bioinformatic of TECNUN, University of Navarra (San Sebastián, Spain)
- Research Group on Molecular Oncology of CIMA, University of Navarra (Pamplona, Spain)
- Research Group on Food Technology, University of Castilla – La Mancha (Spain)
- Research Group on Marine Aquaculture and Physiology (AQUAFISMAR). Universiy of La Laguna e Spanish Institute of Oceanography. (Tenerife, Spain),
- Research Group on Chemiscal y Biotecnology of Natural Products (QUIBIONAT). Departament of Organic Chemistry. Univesity of La Laguna. (Tenerife, Spain)
- Research Group on Statistic of IOBA, Univesity of Valladolid (Valladolid, Spain)
- Research Groups on biomolecular y celular del CiC-IMBCC, Univesity of Salamanca (Salamanca, Spain)
- University General Hospital of Ciudad Real (Ciudad Real, Spain)
- University Hospital Nuestra Señora de la Candelaria. (Tenerife, Spain)
- Institute for Molecular Bioscience, University of Queensland (Brisbane, Australia)
- Oceanographic Institute of the Canary Islands
- Bio-Organic University Institute Antonio González. University of La Laguna (Tenerife, Spain)
- Tropical Diseases and Public Health University Institute of the Canary Islands (Spain)
- S.A.T. Wines Coloman 3753.
Some of the current research lines of the group could be summarize on obtaining Optimal Designs for:
- Nonlinear models.
- Pharmacokinetic models.
- Multifactorial models.
- Compartmental models.
- Survival analysis and censored variables.